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Treatment response : As per NICE guidance, assess response after 6 months and continue only if adequate benefit is demonstrated (HbA1c reduction of at least 11 mmol/mol [1%] and/or 3% weight loss from initial body weight)

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Batsis, Prado, and colleagues, writing in Annals of Internal Medicine , applied prespecified benchmarks for expected muscle-related losses about 25% of total weight loss for FFM or lean soft tissue measured by BIA or DXA, and about 15% for skeletal muscle measured by CT or MRI

Semaglutide is co-formulated with sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC), a delivery carrier to enhance gastrointestinal absorption [201]

Fibre also helps regulate blood glucose levels and promotes satiety