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This study highlights that treatment discontinuation, especially early, negatively affects both weight and glycemic control outcomes. The most common reasons for discontinuation of treatment included the cost of the medications and insurance coveragerelated issues, side effects, and medication shortages

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Table 12: Results at Week 24 (LOCF*) in an Active-Controlled Trial of Dapagliflozin Initial Combination Therapy with Metformin HCl Extended-Release in Adults with Type 2 Diabetes Mellitus Dapagliflozin Add-On To Metformin HCl Immediate-Release A total of 546 adult patients with type 2 diabetes mellitus with inadequate glycemic control (HbA1c 7% and 10%) participated in a 24-week, placebo-controlled trial to evaluate dapagliflozin in combination with metformin HCl (NCT00528879)