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Graphic abstract Similar content being viewed by others Introduction Depression is a chronic and recurrent mood disorder and one of the major health concerns in modern society, which, according to the World Health Organization (WHO), affects more than 264 million people worldwide

95% CI, 4.13 to 214.2

2018The incretin hormone GIP is upregulated in patients with atherosclerosis and stabilizes plaques in ApoE(-/-) mice by blocking monocyte/macrophage activation

52 These results, in part, supported the development of orforglipron as an orally delivered GLP-1RA in clinical testing