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When dietary protein intake drops during rapid weight loss, the body's ability to maintain these tissues can be compromised

Some debate exists about long-term use since obesity tends to be chronic, these medications likely need to be continued to maintain weight loss (as stopping leads to regain, based on observations)

The pivotal role of high glucose-induced overexpression of PKC in the appearance of glucagon-like peptide-1 resistance in endothelial cells

Additionally, GLP-1 medications can slightly relax the lower esophageal sphincter, which is the trap door meant to keep acid inside the stomach