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Beyond the improved glycaemia control, essential for the short term treatment of diabetes (188), different GLP-1RAs are powerful clinical tools for the management of diabetic kidney disease (DKD) (189) non-alcoholic steatohepatitis (NASH) (190), neuroinflammation (191), obesity and cardiovascular disease (192195)

By week 12, clinical trial data shows average weight loss of 5-7% of starting body weight

Cardiovascular considerations exist with both classes of compounds
