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Liver Fat Reduction in MASLD Nature Medicine 2024 This substudy analyzed participants with significant liver steatosis

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Our observations indicate that Exendin-4 treatment ameliorated anxiety symptoms in mice undergoing heroin withdrawal, yet paradoxically exacerbated anxiety-like behaviors in the saline control group

However, these findings require replication, and the specific contribution of tirzepatide's dual GIP/GLP-1 mechanism remains unclear

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