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Pre-B cell colony-enhancing factor (PBEF)/visfatin: a novel mediator of innate immunity

SGLT2 inhibitors have revolutionized the treatment of patients with type 2 DM (T2DM) with established or at risk for atherosclerotic cardiovascular disease (ASCVD) and patients with diabetic kidney disease.2, 3, 4, 5 The beneficial effects from SGLT2 inhibitors are apparent shortly after drug initiation suggesting mechanisms independent of glycemic control

Whilst both are licensed for weight management in the UK, they differ significantly in how they work, administration routes, side effect profiles, clinical effectiveness, and NHS accessibility

Dickson SL, Egecioglu E, Landgren S, Skibicka KP, Engel JA, Jerlhag E

Onset of these reactions occurred within the first 3 months after initiation of treatment with JANUVIA, with some reports occurring after the first dose