glp 1 glucagon dual receptor agonist Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research Machine learning designs new GCGR/GLP-1R

It is notable that high spikes of blood insulin, (Hyperinsulinemia), initiates inflammation, which over times causes atherosclerosis and its sequela cardiovascular heart disease (CHD)

Real-world studies have shown heterogeneous findings

MECHANISM OF ACTION GLP-1 analogs Glucagon-like peptide-1 (GLP-1) is a hormone secreted into the bloodstream by special cells in the intestine in response to food consumption

Causal factors for knee, hip, and hand osteoarthritis: a Mendelian randomization study in the UK biobank

The American Diabetes Association's Standards of Care acknowledge the ongoing uncertainty, noting that while pancreatitis has been reported with GLP-1 receptor agonist use, a definitive causal relationship has not been established