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These findings, together with the convenience of oncedaily oral dosing and onceweekly injection, support the use of these medications in this prediabetic population. Karen Elkind-Hirsch Elkind-Hirsch and colleagues recruited 119 premenopausal women aged 18 to 45 years with obesity and PCOS and without diabetes to participate in the study

Specifically, while obesity surgery and LIRA/PYY 3-36 co-administration resulted in comparable changes in body weight in obese rats, only surgery resulted in profound changes to the hypothalamic transcriptome

Nathanson D, Erdogdu O, Pernow J, Zhang Q, Nystrom T: Endothelial dysfunction induced by triglycerides is not restored by exenatide in rat conduit arteries ex vivo
Regulation of vasomotor functions and arterial blood pressure GLP-1 has been demonstrated to modulate peripheral arterial blood flow by exerting direct effects or via signals from the CNS
