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Gastrointestinal events occurred slightly more often with semaglutide (79.0%) than tirzepatide (76.7%) and were the leading cause of discontinuation: 5.6% versus 2.7% respectively [41]

But in my 25+ years of practice, the most transformative medications Ive seen in terms of effectiveness and safety are the class of drugs known as glucagon-like peptide 1 (GLP-1) agonists

The Negative Experiences But mixed in with the praise were some very real frustrations

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