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Therefore, for patients being overweight/obese with diabetes, both domestic and international guidelines and expert consensus recommend prioritizing weight-neutral or weight-reducing medications when selecting glucose-lowering treatment plans

While base-case results suggested numerically lower cost of control for semaglutide at moderate weight loss targets (10% and 15%) and for tirzepatide at higher thresholds (20%, 25%, and 30%), these differences were not statistically significant

Among these effects are those on the heart and blood vessels, which include regulating hunger, inhibiting gastric acid secretion and gastric emptying, controlling glucose generation in the liver, and so on [28]

Appetite suppression is more consistent

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