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GIP also appears to reduce the nausea commonly associated with pure GLP-1 agonists
For threshold, I think of seizure medications, warfarin, and ADHD meds as well as some psychotropics

Week one is often about getting through the adjustment

NICE guidance on obesity management acknowledges that pharmacological interventions should be considered as part of a multicomponent approach

From dearth to excess: the rise of obesity in an ultra-processed food system