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In the SURMOUNT-1 trial with 2,539 adults with obesity, participants on the highest tirzepatide dose (15 mg weekly) lost an average of 20.9% of their body weight over 72 weeks

As an example, he points to Novo Nordisks Rybelsus (oral semaglutide), which uses an absorption enhancer to temporarily permeabilize the stomach lining

Additionally, individuals should seek medical attention if they experience severe pain or persistent side effects while using this medication

This early checkpoint provides a practical opportunity to reassess treatment strategies rather than continuing ineffective interventions

Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome