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Though these drugs have been deemed effective in treating T2DM, the Food and Drug Administration (FDA) and some members of the scientific community have questioned the safety of these therapeutics relative to important cardiovascular endpoints

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80 4 mg 19.0% weight loss 9 mg 25.9% weight loss 12 mg 28.3% weight loss Placebo 2.2% 45.3% of participants on the highest dose lost 30% of their body weight a threshold historically associated with bariatric surgery

With semaglutide patent expiry expected next year, competitive entry could pull prices down from current ~1726k/month and accelerate adoption