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7.0% to 10.5% [53 to 91 mmol/mol] for SUSTAIN 2 and 3) were randomized to semaglutide 0.5 mg, semaglutide 1.0 mg or a comparator: placebo (SUSTAIN 1, 5), sitagliptin 100 mg (SUSTAIN 2), exenatide ER (SUSTAIN 3), and titrated insulin glargine (SUSTAIN 4) for 30 or 56 weeks.15, 16, 17, 18, 19 Subjects were followed throughout the planned trial period

Mechanisms linking the gut microbiome and glucose metabolism

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FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of beta cells during acute metabolic stress