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Adrenergic and muscarinic receptors have been reported to be differentially expressed in different sites of the sinus node, consistent with the shifts in sites of earliest activation upon autonomic modulation

doi: 10.1016/0196-9781(96)00019-8
20 BurmeisterM

However, recent evidence demonstrates that this regulation may not be necessary for the maintenance of whole body glucose metabolism, at least in mice
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