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Mayo Clinic notes that approximately 25% to 40% of weight lost during GLP-1 therapy may come from lean mass (which includes water, organs, bone, connective tissue, and skeletal muscle, not muscle alone)
doi: 10.1073/pnas.0610787104 195 MerchenthalerILaneMVNumanSDellovadeTL
But a Facebook group is not medical care
However, the FDA issued a Complete Response Letter (CRL) in late 2025 due to third-party manufacturing issues (Catalent facility), completely unrelated to the drugs safety or efficacy
SUSTAIN-6 PubMed abstract
