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Importantly, the positive cardiovascular effects of liraglutide were sustained in mice with myeloid cell Glp1r deficiency but were eliminated in Glp1r / mice and endothelial cell-specific Glp1r knockout mice (Helmstadter et al
This finding has been corroborated across different preclinical models, where impaired BCAA catabolic activities and increased BCAA levels were observed in the several preclinical HFpEF models 93,94

As a physician, Narang is concerned that the buzz around GLP-1s is shifting attention to medication rather than treating diabetes and obesity as chronic conditions that require long-term, holistic care and medical follow-up

General Guidance: Frequent missed doses may compromise glycemic control and weight management outcomes
