contraindications for glp-1 agonists include Safety and Tolerability of Glucagon-Like Peptide-1 Receptor Agonists: A State-of-the-Art Narrative Review | Drugs What Are GLP-1 Medications? A
Description
Intervention: Any GLP-1 receptor agonist, including liraglutide, semaglutide, dulaglutide, exenatide, or lixisenatide

[10] It aims to recruit 14,000 subjects

Findings: RCTSTEP 3 Trial - Wegovy vs Placebo for Weight Loss in Overweight Adults Without DM, JAMA (2021) [PubMed abstract] Design: Randomized, placebo-controlled trial (N=611 | length = 68 weeks) in overweight or obese adults (average weight 233 lbs | average BMI 38) without diabetes Treatment: Wegovy 2.4 mg sub-q once weekly vs Placebo

Its role in the alternatives landscape is more about metabolic optimization than aggressive weight loss

High fat diet and GLP-1 drugs induce pancreatic injury in mice
