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The most common microdosing methods include staying on the starting dose for a longer duration, reducing injection frequency by counting the clicks, or splitting and diluting pens
Typically, treatment begins with a lower dose to minimize side effects, gradually increasing over time until achieving a maintenance dosage
Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 diabetes mellitus: A meta-analysis
doi: 10.1016/j.tig.2019.01.001 53
Additionally, thermosensitive nanogels and stimuli-responsive nanocarriers that respond to pH or glucose levels have been proposed for precision-controlled GLP-1 delivery, enabling intelligent drug release based on glycemic fluctuations
