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Studies comparing oral glucose and equivalent amounts of intravenous glucose have found that oral glucose intake led to a greater than 50% increase in insulin response, which was attributed to the incretin effect [89]

It also reduces the risk of cardiovascular death, heart attack and stroke in patients who have overweight or obesity

Older adults using Wegovy were slightly less likely to have a bone or joint injury compared with those taking a placebo, although Wegovy users were slightly more prone to falls than those assigned to take a placebo (4.4% of the Wegovy group had a documented fall, compared with 3.6% of the placebo group)

By simultaneously targeting the Glucagon-like peptide-1 (GLP-1), Glucose-dependent insulinotropic polypeptide (GIP), and Glucagon receptors, this peptide provides a multi-dimensional approach to studying metabolic homeostasis

Guideline Recommendations Guidelines and expert consensus on the clinical use of GLP-1RAs suggest that GLP-1RAs reduce cardiovascular risk in T2DM (eg, 2020 Chinese Guidelines for the Prevention and Control of Type 2 Diabetes Mellitus, 2022 Chinese Clinical Guidelines for the Prevention and Control of Type 2 Diabetes Mellitus in the Elderly, and 2023 American Diabetes Association Standards for the Medical Diagnosis and Treatment of Diabetes Mellitus)