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Description
It arises due to a combination of genetic and lifestyle factors that contribute to defective production of insulin from pancreatic beta cells, and/or resistance to its uptake by insulin receptors located in peripheral and central tissues in the body
Additionally, GLP-1 can inhibit apoptosis by activating the PI3K/Akt pathway, promoting the anti-apoptotic protein Bcl-2 and hindering the activity of caspases
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N.HolscherC.YuanL.YangW.WangX
showed a dose-dependent reduction in food intake with GLP-1 infusion in 16 healthy male subjects [9]
