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Acute kidney injury nausea, vomiting, and diarrhea can cause dehydration, which may affect kidney function

Over time, these changes can make it difficult to meet energy and nutrient needs, maintain lean mass, or build sustainable habits around food

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Semaglutide (Wegovy) typically follows this schedule: Weeks 1-4: 0.25 mg Weeks 5-8: 0.5 mg Weeks 9-12: 1.0 mg Weeks 13-16: 1.7 mg Week 17+: 2.4 mg (maintenance) Tirzepatide (Zepbound) uses a similar approach: Weeks 1-4: 2.5 mg Weeks 5-8: 5 mg Weeks 9-12: 7.5 mg Weeks 13-16: 10 mg Week 17+: 12.5 mg or 15 mg (if tolerated) Do not self-adjust doses

26 Late responders also tended towards a higher baseline body weight