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Being totally sedentary, which is very bad for blood sugar control

Early GLP-1 development efforts were hindered by rapid degradation by dipeptidyl peptidase-4, short duration of action, and gastrointestinal intolerance at supraphysiologic exposure levels

Thats not a reason to ignore it, but it is a reason not to panic

Three caveats constrain the reward story

Wanting to have more energy to play outside with her son, she started walking more in her Iowa town, eventually challenging herself to run one mile daily on the treadmill in 2022
