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Tirzepatide is a dual GLP-1 and GIP receptor agonist that works by slowing stomach emptying and increasing feelings of fullness, but approximately 2540% of users experience mild to moderate gastrointestinal symptoms during the first weeks of treatment

Early research suggests this effect accounts for 2-4% of additional weight loss beyond what dual agonism achieves, a number that compounds significantly over a 48 to 68 week treatment period

Surg Endosc

Common side effects by dose tier Most side effects follow a predictable pattern

If an infant ingested trace amounts through breast milk, their stomach acid and digestive enzymes would likely degrade the medication just like a dietary protein, making systemic absorption into the bloodstream unlikely., Is tirzepatide (Zepbound or Mounjaro) safe for breastfeeding