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The carriers of the loss-of-function GIP receptor variants, R190Q and E288G, display higher blood pressure and an increased tendency toward hypertension (99) but a comprehensive study of larger number of loss-of-function GIP receptor variants did not reveal similar effects on cardiovascular traits (39)

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The study, published in Nature Communications , provides some of the strongest human evidence to date that a GLP-1 drug may affect molecular pathways tied to aging itself

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.GLP-1 receptor agonists for prevention of cardiorenal outcomes in type 2 diabetes: an updated meta-analysis including the REWIND and PIONEER 6 trials

Strength training just a few times a week can help maintain muscle, bone density, and metabolism while the medication works on appetite regulation