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This was the case when treatment was administered during the conditioning phase and also during the expression phase (Egecioglu, Steensland, et al., 2013

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The percentage of patients who discontinued due to ineffective therapy was 0.9% in the liraglutide injection 1.8 mg + metformin + glimepiride treatment group, 0.4% in the insulin glargine + metformin + glimepiride treatment group, and 11.3% in the placebo + metformin + glimepiride treatment group

As a result of this, the PCDS and the Association of British Clinical Diabetologists have updated their joint guidance to assist healthcare professionals to overcome this particular challenge in the management of type 2 diabetes in adults