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If one averages the effect on A1c of the highest doses for each drug in a specific drug class the reductions in A1c for each class of drug are metformin 1.09%, sulfonylureas 1.0%, TZDs 0.95%, DPP-4 inhibitors 0.66%, SGLT2 inhibitors 0.83%, and GLP-1 RAs 1.24%

The prevalence of comorbid diagnoses of sarcopenia and obesity has substantially risen over recent years, where many individuals with obesity under the age of 65 now have sarcopenic levels of muscle mass [162]

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GLP-1 can impact areas that influence dopamine, the feel-good chemical involved in motivation, reward, and impulse control all things that are closely linked to ADHD

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