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Key Takeaways Injectable GLP-1 medications like Mounjaro demonstrate proven weight loss of 15-20%, while patches lack scientific evidence of effectiveness

And as demand continues to grow, what factors will determine whether patients can start and adhere to treatment long term

The rate of osteoporosis, a disease where the bones become fragile and brittle, was 3.2% in the group not taking the drug, compared to 4.1% in the GLP-1-taking group

Best to reduce the dose and frequency over several weeks time to avoid rebound reflux symptoms

In type 2 diabetes rat models, where bone mass is often reduced, contrary to humans, where bone mass is often normal or increased, liraglutide administration in the range of ~ 110160 nmol/kg/day resulted in increased trabecular BMD and restoration of trabecular microarchitecture parameters in the appendicular and axial skeleton [6367]