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A synthesis method and technology of semaglutide, applied in the field of polypeptide drug production, can solve the problems of high separation and purification, limited coupling site, purification of polypeptide fragments, etc., and achieve the solution of purification difficulty, alleviation of difficulty and rapid transformation

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In a 48-week clinical trial in obese adults, it showed weight reduction of up to 24.2%.

Methods In the PIONEER trials, people with type 2 diabetes were randomised to orally administered semaglutide versus placebo (PIONEER 1, 4, 5 and 8), empagliflozin (PIONEER 2), sitagliptin (PIONEER 3) and liraglutide (PIONEER 4) for 2678 weeks

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