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Anxiety has emerged as a reported side effect in some patients taking semaglutide, affecting approximately 5-8% of users in real-world data

Insulin resistance in this group of patients results from defects at the molecular level, including impaired insulin receptor-related signaling pathways enhanced by obesity and its features: Excess visceral fat, chronic inflammation, and reactive oxygen species

Nearly three-quarters of Americans are living with overweight or obesity, and therefore at higher risk for chronic and debilitating conditions such as diabetes and heart disease

Chief amongst the various hormones that are secreted from the EECs is GLP-1, a peptide whose actions result in the regulation of circulating glucose, the control of appetite, and the motivation for food intake
