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The beverage has been consumed for centuries in Paraguay, Argentina, and Uruguay as part of social tradition and for its stimulating effects

In: Feingold KR, Anawalt B, Blackman MR et al (eds) Endotext [Internet]

While metformin remains the first-line treatment for T2D, GLP-1s may be used in combination with metformin for additional benefits

As they target several aspects of metabolic health, they are valuable tools for managing obesity and T2DM [6,71]

Injectable GLP-1RAs face limitations such as injection frequency and side effects, prompting the investigation of natural compounds that can modify GLP-1 function as alternative treatments