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Since different dose forms of semaglutide were approved for different disease indications, we could not directly examine the dosage effect of semaglutide in our study

this suggests a rapid phase of GLP-1 secretion caused by direct stimulation of L-cells in the upper GI tract and a second phase potentially caused by signals from the upper gut reaching the lower small and perhaps even the large intestine [323,324]

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Berberine activates the -catenin/TCF4 signaling pathway by down-regulating miR-106b to promote GLP-1 production by intestinal L cells