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Managing Side Effects During the Critical First Weeks Eating smaller, frequent meals rather than three large ones dramatically reduces nausea severity in the first one to two weeks, as this practice minimizes gastric distension and slows the pace of your stomach emptying further

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Phase 1b/2a results (published in The Lancet, 2025): - In 125 adults with overweight or obesity, the subcutaneous 20 mg dose achieved 22.0% absolute weight loss (23.9% placebo-adjusted)

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Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushings syndrome