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Rethinking the Therapy Algorithm Mar 19, 2026 Articles, Diabetes, GLP- 1 Agonist Therapy Center, GLP-1 Agonist Therapy Center, Therapies, Type 2 Diabetes, Type 2 Diabetes 1,718 views Managing type 2 diabetes today can feel like solving a moving puzzle

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Brian Wojeck, an obesity medicine specialist at the Yale School of Medicine, likened it to what happens after bariatric surgery, in which patients often experience temporary shedding due to stress and rapid metabolic change

Losartan is an angiotensin II receptor blocker (ARB) widely prescribed in the UK for conditions including hypertension, diabetic nephropathy, and where ACE inhibitors are not tolerated heart failure, in line with the British National Formulary (BNF) and UK Summary of Product Characteristics (SmPC)

One current example of polypharmacology in the clinic is Eli Lillys investigational drug Retatrutide, which acts as a triple agonist against glucagon, GIP, and GLP-1 receptors (Figure 1), engendering even greater weight loss in clinical trials than approved blockbuster drugs Semaglutide (GLP1-R agonist) and Tirzepatide (dual GLP1-R/GIP agonist)