first large study of glp 1 receptor agonists during pregnancy Taking GLP-1s the trimester does not appear to substantially increase the risk of adverse outcomes Discontinuing GLP-1s Before or Early
Description
Author Contributions All authors contributed to the conception and design of the study

Toft-Nielsen MB, Damholt MB, Madsbad S, Hilsted LM, Hughes TE, Michelsen BK, et al

Differences also exist within drug classes

Emerging dual agonists, such as tirzepatide (GLP-1/GIP) and pemvidutide or efinopegdutide (GLP-1/glucagon), have shown superior efficacy in promoting weight loss, improving hepatic and systemic inflammation, and enhancing cardiometabolic parameters

25 In the early 1990s, despite John Engs team identifying a potential diabetes treatment in exendin-4, it initially lacked attention and funding for development
