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Semaglutide-treated hepatocytes also had increased expression of genes related to adipocytokine signalling, glucagon signalling, AMPK signalling, insulin signalling, and steroid hormone biosynthesis compared to hepatocytes of vehicle-treated animals ( Figure 6E )

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Side Effects and Safety: What the Data Shows The side effect profile is broadly similar to Wegovy and Mounjaro but with some unique additions due to the glucagon mechanism

Agitation: Vigorous shaking can cause peptides, especially in liquid form, to shear or form aggregates (clumps), which deactivates them
