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32 Since tirzepatide does not have a GIP (3142) tail, chosen Ala 21 was likely to increase the GLP-1 activity, despite it slightly decreasing the GIP activity

The combination of these mechanisms could explain the superior glycemic control observed with tirzepatide compared to GLP-1 receptor agonists alone

Tips for managing injection site reactions Similar to other diabetes and weight-loss medications that use injections, site reactions tend to occur more commonly if you're doing the injections at the same place on your body each time, says Sowa

Taking the injection before bed allows you to sleep through the peak of initial nausea, which typically occurs 6 to 12 hours after administration

It is about preserving functional independence
