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Three of the top five drugs driving the net change in costs per member per month (PMPM) were GLP-1 agonists

Its physiological actions include stimulating glucose-dependent insulin secretion from pancreatic beta cells, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Triglycerides, Adiponectin, and QUICKI were independent variables in predicting the degree of hepatic steatosis

This position is supported by the results of a recent study that suggest that achieving a HbA1c target of 300 mg/g), lixisenatide reduced the placebo-adjusted mean percentage change in UACR by 39.2% (95% confidence interval 9.8 to 68.5%

Anecdotal user reports support this, and the postbiotic mechanism for gut barrier support is plausible