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2021;doi:10.1056/NEJMoa2028395) where semaglutide improved steatohepatitis and slowed fibrosis progression, but regression of liver fibrosis fell short of reaching statistical significance

Control outcome analysis To explore potential mechanisms underlying the observed associations, we evaluated changes in metabolic parameters, including HbA1c and body mass index (BMI), as positive control outcomes

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Participants in the highest quartile of total logs per month experienced 2.0% (95% CI: 2.4, 1.6) greater weight loss, 0.65 kg/m 2 (95% CI: 0.79, 0.52) greater BMI reduction, and 2.9 mmHg (95% CI: 5.0, 0.9) greater reduction in systolic blood pressure, compared to those in the lowest quartile

Many people lose several pounds during this period