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Understanding this dual role has important therapeutic implications, as G protein-biased GLP-1 receptor agonists with reduced -arrestin recruitment show enhanced anti-hyperglycemic efficacy through avoidance of receptor desensitization, while the requirement for -arrestin-2 in ERK/CREB activation at therapeutic concentrations explains why complete elimination of -arrestin-2 recruitment may not be optimal for all applications

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392:427-437 [PubMed: 39555826] 401

Note severity, duration, and triggers for nausea, vomiting, diarrhea, constipation, or other symptoms