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INDICATION AND LIMITATIONS OF USE BYDUREON BCise is indicated as an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients aged 10 years and older with type 2 diabetes mellitus Not recommended as first-line therapy for patients inadequately controlled on diet and exercise Not indicated to treat type 1 diabetes Do not coadminister with other exenatide-containing products Not studied in patients with a history of pancreatitis

To overcome these limitations, this review discusses a range of structural modifications, including N-terminal and C-terminal substitutions, fatty acid conjugation, and large molecule fusion technologies, which have collectively contributed to enhanced half-life, increased stability, improved receptor affinity, and retained or augmented bioactivity of GLP-1 analogs