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Following the initial top-line readout in August which showed a statistically significant, 20% relative risk reduction in MACE-3 cardiovascular events the veil has finally been lifted from the landmark SELECT cardiovascular outcomes trial

GLP-1 RAs provide sustained central and peripheral GLP-1R activation that blunts appetite via hypothalamusvagusNTS circuits, improves metabolic health, and may reduce alcohol and other substance-related craving and reward signals.

But these effects may be mitigated through physical activity modification