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Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure N Engl J Med

The SUSTAIN-6 trial showed reduced risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease

The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors

Fruzaqla targets the VEGF-1, -2 and -3 receptors, which together play a crucial role in the formation of the blood vessels that sustain tumors

Vosoughi K et al