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Several systematic reviews on subcutaneous semaglutide or oral semaglutide have recently been published, but their focus is primarily on efficacy and safety, rather than pharmacokinetics.6466 In addition, a few of population pharmacokinetic models were established using data from selected clinical pharmacological trials to identify clinically relevant covariates of exposure, but they included limited trial data.50,53,54 The limitation of this review is that we only searched two databases, so it is possible that we missed one study, which may reduce the validity and subsequent reliability of the findings

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