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Description
Levey, J
Front Endocrinol (Lausanne) 2012;3:158.PubMedPMC 39

Here, we have compared the glucagonostatic effects of GLP-1(736) and (936) in vitro using physiological (pmol/l) concentrations of the peptides and over a wider range of glucose concentrations in isolated mouse and human islets (some from donors with type 2 diabetes) and extend these data to the in vivo situation with a particular focus on the counterregulatory increase in plasma glucagon during insulin-induced hypoglycaemia

b , Mouse brain images showing heatmap of averaged changes in cFOS expression in response to treatments relative to vehicle
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