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Glossary HYPOTHALAMOPITUITARYADRENAL (HPA) AXIS The neuroendocrine and immune systems communicate bidirectionally through shared ligands and receptors

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Additionally, c-fos (a neuronal activation indicator) was significantly enhanced in the arcuate nucleus (ARC) within 23 hours after tofogliflozin treatment, suggesting that tofogliflozin could permeate these regions and bind to receptors on the ARC