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It is a requirement backed by clinical trial data showing that slower titration reduces gastrointestinal side effects by 40 to 60% compared to starting at full dose
Furthermore, the discrepancy in patient numbers between the two groups can be attributed, at least in part, to the relative novelty of semaglutide as a therapeutic agent

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2014 Jun 11 [cited 2018 Oct 17];311(22):2297304