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Compounded semaglutide and tirzepatide are not FDA-approved medications

6 Alternatively, some patients may be prescribed sulfonylureas or thiazolidiniones to improve insulin secretion, but both of these treatment options are associated with an elevated risk of heart failure making them unsuitable for use in patients with cardiovascular disease

Some key messages and common themes emerge

A well-designed network meta-analysis (NMA) of GLP-1 receptor agonists and SGLT2 inhibitors, which allows for direct comparisons among different medications, could enhance the ability to make multiple treatment efficacy comparisons and assess the potential superiority of specific interventions at various dosages [12]

Microdosing Protocols: Starting Low: Microdosing regimens typically begin with doses as low as 0.1mg to 0.25mg, significantly lower than conventional doses used in diabetes treatment