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Quick Answer: GLP-1 receptor agonists have not been definitively shown to directly cause clinically significant bone density loss, though the substantial weight reduction they produce may indirectly affect bone metabolism

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Zhang Q, Delessa CT, Augustin R et al (2021) The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

[DOI] [PubMed] [Google Scholar] 3.Athanasaki A, et al

Quick Answer: The standard schedule for tirzepatide is one injection every seven days